3PNF

Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2-chlorophenyl)ethyl)amino)ethoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine

3PNF の概要

• エントリーDOI: 10.2210/pdb3pnf/pdb
• 関連するPDBエントリー: 3PNE 3PNG 3PNH
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: heme enzyme, inhibitor, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• 細胞内の位置: Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100373.85

構造登録者

Li, H.,Delker, S.,Poulos, T.L. (登録日: 2010-11-18, 公開日: 2011-11-02, 最終更新日: 2023-09-06)

• 主引用文献: Xue, F.,Kraus, J.M.,Labby, K.J.,Ji, H.,Mataka, J.,Xia, G.,Li, H.,Delker, S.L.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.; Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase.; J.Med.Chem., 54:6399-6403, 2011; PubMed: 21809851; DOI: 10.1021/jm200411j

実験手法

X-RAY DIFFRACTION (1.94 Å)