3PNE
Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(3-chlorophenyl)ethyl)amino)ethoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine
Summary for 3PNE
Entry DOI | 10.2210/pdb3pne/pdb |
Related | 3PNF 3PNG 3PNH |
Descriptor | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
Functional Keywords | heme enzyme, inhibitor, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Rattus norvegicus (brown rat,rat,rats) |
Cellular location | Cell membrane, sarcolemma ; Peripheral membrane protein : P29476 |
Total number of polymer chains | 2 |
Total formula weight | 100373.85 |
Authors | Li, H.,Delker, S.,Poulos, T.L. (deposition date: 2010-11-18, release date: 2011-11-02, Last modification date: 2023-09-06) |
Primary citation | Xue, F.,Kraus, J.M.,Labby, K.J.,Ji, H.,Mataka, J.,Xia, G.,Li, H.,Delker, S.L.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase. J.Med.Chem., 54:6399-6403, 2011 Cited by PubMed: 21809851DOI: 10.1021/jm200411j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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