3PL7

Crystal structure of Bcl-xL in complex with the BaxBH3 domain

Summary for 3PL7

• Entry DOI: 10.2210/pdb3pl7/pdb
• Related: 3PK1
• Descriptor: Bcl-2-like protein 1, Apoptosis regulator BAX (3 entities in total)
• Functional Keywords: bcl-2 family fold, regulation of apoptosis, bax, mitochondria, apoptosis-apoptosis regulator complex, apoptosis/apoptosis regulator
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform Bcl-X(L): Mitochondrion inner membrane (By similarity): Q07817; Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Isoform Beta: Cytoplasm. Isoform Gamma: Cytoplasm. Isoform Delta: Cytoplasm (Potential): Q07812
• Total number of polymer chains: 3
• Total formula weight: 45447.22

Authors

Czabotar, P.E.,Colman, P.M. (deposition date: 2010-11-14, release date: 2010-12-29, Last modification date: 2023-11-01)

• Primary citation: Czabotar, P.E.,Lee, E.F.,Thompson, G.V.,Wardak, A.Z.,Fairlie, W.D.,Colman, P.M.; Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis; J.Biol.Chem., 286:7123-7131, 2011; PubMed: 21199865; DOI: 10.1074/jbc.M110.161281

Experimental method

X-RAY DIFFRACTION (2.613 Å)