3PJ2

Crystal structure of BTK kinase domain complexed with 2-[4-(2-Diethylamino-ethoxy)-phenylamino]-6-(4-fluoro-phenoxy)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one

3PJ2 の概要

• エントリーDOI: 10.2210/pdb3pj2/pdb
• 関連するPDBエントリー: 3PIX 3PIY 3PIZ 3PJ1 3PJ3
• 分子名称: Tyrosine-protein kinase BTK, 2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-6-(4-fluorophenoxy)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (3 entities in total)
• 機能のキーワード: helix c-out, dfg-in, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): Q06187
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32305.05

構造登録者

Kuglstatter, A.,Wong, A. (登録日: 2010-11-08, 公開日: 2011-01-12, 最終更新日: 2023-09-06)

• 主引用文献: Kuglstatter, A.,Wong, A.,Tsing, S.,Lee, S.W.,Lou, Y.,Villasenor, A.G.,Bradshaw, J.M.,Shaw, D.,Barnett, J.W.,Browner, M.F.; Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.; Protein Sci., 20:428-436, 2011; PubMed: 21280133; DOI: 10.1002/pro.575

実験手法

X-RAY DIFFRACTION (1.75 Å)