3PJ1
Crystal structure of BTK kinase domain complexed with 3-(2,6-Dichloro-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one
Summary for 3PJ1
Entry DOI | 10.2210/pdb3pj1/pdb |
Related | 3PI2 3PI3 3PIX 3PIY 3PIZ |
Descriptor | Tyrosine-protein kinase BTK, 3-(2,6-dichlorophenyl)-7-({4-[2-(diethylamino)ethoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (3 entities in total) |
Functional Keywords | helix c-in, dfg-in, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q06187 |
Total number of polymer chains | 1 |
Total formula weight | 32858.39 |
Authors | Kuglstatter, A.,Wong, A. (deposition date: 2010-11-08, release date: 2011-01-12, Last modification date: 2023-09-06) |
Primary citation | Kuglstatter, A.,Wong, A.,Tsing, S.,Lee, S.W.,Lou, Y.,Villasenor, A.G.,Bradshaw, J.M.,Shaw, D.,Barnett, J.W.,Browner, M.F. Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures. Protein Sci., 20:428-436, 2011 Cited by PubMed: 21280133DOI: 10.1002/pro.575 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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