3PIK

Outer membrane protein CusC

Summary for 3PIK

Entry DOI	10.2210/pdb3pik/pdb
Descriptor	Cation efflux system protein cusC, UNKNOWN LIGAND, SULFATE ION, ... (4 entities in total)
Functional Keywords	beta-barrel, lipoprotein, outer membrane, heavy metal efflux pump, modified at the n-terminus with diacylglycerol and palmitate, transport protein
Biological source	Escherichia coli
Cellular location	Cell outer membrane; Lipid-anchor (Potential): P77211
Total number of polymer chains	1
Total formula weight	50064.42
Authors	van den Berg, B. (deposition date: 2010-11-06, release date: 2011-02-02, Last modification date: 2024-11-20)
Primary citation	Kulathila, R.,Kulathila, R.,Indic, M.,van den Berg, B. Crystal Structure of Escherichia coli CusC, the Outer Membrane Component of a Heavy Metal Efflux Pump. Plos One, 6:e15610-e15610, 2011 Cited by PubMed Abstract: While copper has essential functions as an enzymatic co-factor, excess copper ions are toxic for cells, necessitating mechanisms for regulating its levels. The cusCBFA operon of E. coli encodes a four-component efflux pump dedicated to the extrusion of Cu(I) and Ag(I) ions. PubMed: 21249122 DOI: 10.1371/journal.pone.0015610 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation