3PG3

Human p38 MAP Kinase in Complex with RL182

3PG3 の概要

• エントリーDOI: 10.2210/pdb3pg3/pdb
• 関連するPDBエントリー: 3IW8
• 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-{4-[2-(pyridin-3-ylmethoxy)ethyl]-1,3-thiazol-2-yl}urea, ... (4 entities in total)
• 機能のキーワード: dfg-out, sar, kinase domain, thiazole-urea, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42017.96

構造登録者

Gruetter, C.,Simard, J.R.,Getlik, M.,Rauh, D. (登録日: 2010-10-29, 公開日: 2011-11-02, 最終更新日: 2023-09-06)

• 主引用文献: Getlik, M.,Gruetter, C.,Simard, J.R.,Van Otterlo, W.,Robubi, A.,Aust, B.,Rauh, D.; Structure-based design and synthesis of cell active N-pyrazole, N-thiazole urea inhibitors of the MAP kinase p38alpha; To be Published,

実験手法

X-RAY DIFFRACTION (2 Å)