3PEQ

PPARd complexed with a phenoxyacetic acid partial agonist

3PEQ の概要

• エントリーDOI: 10.2210/pdb3peq/pdb
• 分子名称: Peroxisome proliferator-activated receptor delta, [(4-{butyl[2-methyl-4'-(methylsulfanyl)biphenyl-3-yl]sulfamoyl}naphthalen-1-yl)oxy]acetic acid, hexyl beta-D-glucopyranoside, ... (5 entities in total)
• 機能のキーワード: ppar nuclear receptor, transcription-transcription agonist complex, transcription/transcription agonist
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64687.89

構造登録者

Lambert, M.H.,Evans, K.A.,Shearer, B.G.,Wisnoski, D.D.,Shi, D.,Jin, J.,Rivero, R.A.,Sparks, S.M.,Winegar, D.A.,Billin, A.N.,Britt, C.,Way, J.M.,Leesnitzer, L.M.,Merrihew, R.V. (登録日: 2010-10-27, 公開日: 2011-10-12, 最終更新日: 2023-09-06)

• 主引用文献: Evans, K.A.,Shearer, B.G.,Wisnoski, D.D.,Shi, D.,Sparks, S.M.,Sternbach, D.D.,Winegar, D.A.,Billin, A.N.,Britt, C.,Way, J.M.,Epperly, A.H.,Leesnitzer, L.M.,Merrihew, R.V.,Xu, R.X.,Lambert, M.H.,Jin, J.; Phenoxyacetic acid PPARd partial agonists for the treatment of type 2 diabetes: synthesis, optimization, and in vivo efficacy; Bioorg.Med.Chem.Lett., 21:2345-2350, 2011; PubMed: 21414782; DOI: 10.1016/j.bmcl.2011.02.077

実験手法

X-RAY DIFFRACTION (2.4 Å)