3PB7

Crystal structure of the catalytic domain of human Golgi-resident glutaminyl cyclase in complex with PBD150

3PB7 の概要

• エントリーDOI: 10.2210/pdb3pb7/pdb
• 関連するPDBエントリー: 3PB4 3PB6 3PB8 3PB9 3PBB 3PBE
• 分子名称: Glutaminyl-peptide cyclotransferase-like protein, 1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea, ZINC ION, ... (4 entities in total)
• 機能のキーワード: alpha/beta protein, alpha/beta-mixed fold, glutaminyl cyclase, golgi membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Golgi apparatus membrane; Single-pass type I membrane protein: Q9NXS2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37454.55

構造登録者

Huang, K.F.,Liaw, S.S.,Huang, W.L.,Chia, C.Y.,Lo, Y.C.,Chen, Y.L.,Wang, A.H.J. (登録日: 2010-10-20, 公開日: 2011-02-02, 最終更新日: 2023-11-01)

• 主引用文献: Huang, K.F.,Liaw, S.S.,Huang, W.L.,Chia, C.Y.,Lo, Y.C.,Chen, Y.L.,Wang, A.H.J.; Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding; J.Biol.Chem., 286:12439-12449, 2011; PubMed: 21288892; DOI: 10.1074/jbc.M110.208595

実験手法

X-RAY DIFFRACTION (1.4 Å)