3P55

Human carbonic anhydrase II in complex with p-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide

3P55 の概要

• エントリーDOI: 10.2210/pdb3p55/pdb
• 分子名称: Carbonic anhydrase 2, p-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: carbonic anhydrase alpha, lyase, cytosolic
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29938.85

構造登録者

Salmon, A.J. (登録日: 2010-10-07, 公開日: 2011-10-12, 最終更新日: 2023-11-01)

主引用文献

Salmon, A.J.,Williams, M.L.,Hofmann, A.,Poulsen, S.A.
Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors.
Chem.Commun.(Camb.), 48:2328-2330, 2012

PubMed Abstract: We have determined the protein X-ray crystal structures of four organometallic inhibitors in complex with their target enzyme carbonic anhydrase II. The barrel-shaped hydrophobic ferrocene and ruthenocene moieties have provided a structure-based avenue to better occupy the hydrophobic binding patch within the enzyme active site.

PubMed: 22258283
DOI: 10.1039/c2cc15625c

実験手法

X-RAY DIFFRACTION (2 Å)