3P49
Crystal Structure of a Glycine Riboswitch from Fusobacterium nucleatum
Summary for 3P49
| Entry DOI | 10.2210/pdb3p49/pdb |
| Descriptor | GLYCINE RIBOSWITCH, U1 small nuclear ribonucleoprotein A, MAGNESIUM ION, ... (5 entities in total) |
| Functional Keywords | riboswitch, rna, cooperative, glycine, rna binding protein-rna complex, rna binding protein/rna |
| Biological source | Fusobacterium nucleatum subsp. polymorphum More |
| Cellular location | Nucleus: P09012 |
| Total number of polymer chains | 2 |
| Total formula weight | 66463.09 |
| Authors | Butler, E.B.,Wang, J.,Xiong, Y.,Strobel, S. (deposition date: 2010-10-06, release date: 2011-04-06, Last modification date: 2024-02-21) |
| Primary citation | Butler, E.B.,Xiong, Y.,Wang, J.,Strobel, S.A. Structural basis of cooperative ligand binding by the glycine riboswitch. Chem.Biol., 18:293-298, 2011 Cited by PubMed Abstract: The glycine riboswitch regulates gene expression through the cooperative recognition of its amino acid ligand by a tandem pair of aptamers. A 3.6 Å crystal structure of the tandem riboswitch from the glycine permease operon of Fusobacterium nucleatum reveals the glycine binding sites and an extensive network of interactions, largely mediated by asymmetric A-minor contacts, that serve to communicate ligand binding status between the aptamers. These interactions provide a structural basis for how the glycine riboswitch cooperatively regulates gene expression. PubMed: 21439473DOI: 10.1016/j.chembiol.2011.01.013 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.55 Å) |
Structure validation
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