3P49

Crystal Structure of a Glycine Riboswitch from Fusobacterium nucleatum

3P49 の概要

• エントリーDOI: 10.2210/pdb3p49/pdb
• 分子名称: GLYCINE RIBOSWITCH, U1 small nuclear ribonucleoprotein A, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: riboswitch, rna, cooperative, glycine, rna binding protein-rna complex, rna binding protein/rna
• 由来する生物種: Fusobacterium nucleatum subsp. polymorphum; 詳細
• 細胞内の位置: Nucleus: P09012
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66463.09

構造登録者

Butler, E.B.,Wang, J.,Xiong, Y.,Strobel, S. (登録日: 2010-10-06, 公開日: 2011-04-06, 最終更新日: 2024-02-21)

主引用文献

Butler, E.B.,Xiong, Y.,Wang, J.,Strobel, S.A.
Structural basis of cooperative ligand binding by the glycine riboswitch.
Chem.Biol., 18:293-298, 2011

PubMed Abstract: The glycine riboswitch regulates gene expression through the cooperative recognition of its amino acid ligand by a tandem pair of aptamers. A 3.6 Å crystal structure of the tandem riboswitch from the glycine permease operon of Fusobacterium nucleatum reveals the glycine binding sites and an extensive network of interactions, largely mediated by asymmetric A-minor contacts, that serve to communicate ligand binding status between the aptamers. These interactions provide a structural basis for how the glycine riboswitch cooperatively regulates gene expression.

PubMed: 21439473
DOI: 10.1016/j.chembiol.2011.01.013

実験手法

X-RAY DIFFRACTION (3.55 Å)