3P3H

Human carbonic anhydrase II in complex with p-(5-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide

Summary for 3P3H

Entry DOI	10.2210/pdb3p3h/pdb
Related	3P3J
Descriptor	Carbonic anhydrase 2, ZINC ION, p-(5-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide, ... (5 entities in total)
Functional Keywords	carbonic anhydrase alpha, lyase, cytosolic
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	29846.76
Authors	Salmon, A.J. (deposition date: 2010-10-04, release date: 2011-09-28, Last modification date: 2023-11-01)
Primary citation	Salmon, A.J.,Williams, M.L.,Hofmann, A.,Poulsen, S.A. Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors. Chem.Commun.(Camb.), 48:2328-2330, 2012 Cited by PubMed Abstract: We have determined the protein X-ray crystal structures of four organometallic inhibitors in complex with their target enzyme carbonic anhydrase II. The barrel-shaped hydrophobic ferrocene and ruthenocene moieties have provided a structure-based avenue to better occupy the hydrophobic binding patch within the enzyme active site. PubMed: 22258283 DOI: 10.1039/c2cc15625c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation