3OYZ
Haloferax volcanii Malate Synthase Pyruvate/Acetyl-CoA Ternary Complex
Summary for 3OYZ
| Entry DOI | 10.2210/pdb3oyz/pdb |
| Related | 3OYX 3PUG |
| Descriptor | Malate Synthase, ACETYL COENZYME *A, PYRUVIC ACID, ... (8 entities in total) |
| Functional Keywords | tim barrel, transferase |
| Biological source | Haloferax volcanii |
| Cellular location | Cytoplasm : D4GTL2 |
| Total number of polymer chains | 1 |
| Total formula weight | 49342.86 |
| Authors | Howard, B.R.,Bracken, C.,Neighbor, A.,Thomas, G.,Lamlenn, K.K.,Schubert, H.L.,Whitby, F.G. (deposition date: 2010-09-24, release date: 2011-06-01, Last modification date: 2024-04-03) |
| Primary citation | Bracken, C.D.,Neighbor, A.M.,Lamlenn, K.K.,Thomas, G.C.,Schubert, H.L.,Whitby, F.G.,Howard, B.R. Crystal structures of a halophilic archaeal malate synthase from Haloferax volcanii and comparisons with isoforms A and G. Bmc Struct.Biol., 11:23-23, 2011 Cited by PubMed Abstract: Malate synthase, one of the two enzymes unique to the glyoxylate cycle, is found in all three domains of life, and is crucial to the utilization of two-carbon compounds for net biosynthetic pathways such as gluconeogenesis. In addition to the main isoforms A and G, so named because of their differential expression in E. coli grown on either acetate or glycolate respectively, a third distinct isoform has been identified. These three isoforms differ considerably in size and sequence conservation. The A isoform (MSA) comprises ~530 residues, the G isoform (MSG) is ~730 residues, and this third isoform (MSH-halophilic) is ~430 residues in length. Both isoforms A and G have been structurally characterized in detail, but no structures have been reported for the H isoform which has been found thus far only in members of the halophilic Archaea. PubMed: 21569248DOI: 10.1186/1472-6807-11-23 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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