3OXK

Crystal structure of a histidine triad family protein from Entamoeba histolytica, bound to GMP

Summary for 3OXK

• Entry DOI: 10.2210/pdb3oxk/pdb
• Related: 3OJ7 3OMF
• Descriptor: Putative histidine triad family protein, ZINC ION, GUANOSINE-5'-MONOPHOSPHATE, ... (5 entities in total)
• Functional Keywords: ssgcid, nih, niaid, sbri, uw, emerald biostructures, putative hydrolase, structural genomics, seattle structural genomics center for infectious disease, metal binding protein
• Biological source: Entamoeba histolytica
• Cellular location: Nucleus : C4LYI2
• Total number of polymer chains: 1
• Total formula weight: 13491.79

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2010-09-21, release date: 2010-10-06, Last modification date: 2023-09-06)

Primary citation

Lorimer, D.D.,Choi, R.,Abramov, A.,Nakazawa Hewitt, S.,Gardberg, A.S.,Van Voorhis, W.C.,Staker, B.L.,Myler, P.J.,Edwards, T.E.
Structures of a histidine triad family protein from Entamoeba histolytica bound to sulfate, AMP and GMP.
Acta Crystallogr F Struct Biol Commun, 71:572-576, 2015

PubMed Abstract: Three structures of the histidine triad family protein from Entamoeba histolytica, the causative agent of amoebic dysentery, were solved at high resolution within the Seattle Structural Genomics Center for Infectious Disease (SSGCID). The structures have sulfate (PDB entry 3oj7), AMP (PDB entry 3omf) or GMP (PDB entry 3oxk) bound in the active site, with sulfate occupying the same space as the α-phosphate of the two nucleotides. The C(α) backbones of the three structures are nearly superimposable, with pairwise r.m.s.d.s ranging from 0.06 to 0.13 Å.

PubMed: 25945711
DOI: 10.1107/S2053230X1500237X

Experimental method

X-RAY DIFFRACTION (1.55 Å)