3OTU
PDK1 mutant bound to allosteric disulfide fragment activator JS30
Summary for 3OTU
Entry DOI | 10.2210/pdb3otu/pdb |
Related | 3ORX 3ORZ |
Descriptor | 3-phosphoinositide-dependent protein kinase 1, 4-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]-4-oxobutane-1-thiol, 3-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE, ... (6 entities in total) |
Functional Keywords | pif pocket, activation loop, c helix, ser/thr-kinase, agc kinase, allostery, transferase, allosteric activator, bisindolylmaleimide, phosphorylation, disulfide, kinase, pdk1, transferase-transferase activator complex, transferase/transferase activator |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: O15530 |
Total number of polymer chains | 1 |
Total formula weight | 37783.86 |
Authors | Sadowsky, J.D.,Wells, J.A. (deposition date: 2010-09-13, release date: 2011-03-23, Last modification date: 2023-09-06) |
Primary citation | Sadowsky, J.D.,Burlingame, M.A.,Wolan, D.W.,McClendon, C.L.,Jacobson, M.P.,Wells, J.A. Turning a protein kinase on or off from a single allosteric site via disulfide trapping. Proc.Natl.Acad.Sci.USA, 108:6056-6061, 2011 Cited by PubMed: 21430264DOI: 10.1073/pnas.1102376108 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1013 Å) |
Structure validation
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