3OQF
Crystal Structure Analysis of Renin-indole-piperazine inhibitor complexes
Summary for 3OQF
| Entry DOI | 10.2210/pdb3oqf/pdb |
| Related | 3OOT 3OQK |
| Descriptor | Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-benzyl-1-phenyl-3-(piperazin-1-ylcarbonyl)-1H-indole, ... (4 entities in total) |
| Functional Keywords | renin human, aspartyl protease, renin inhibition, hypertension, hydrolase |
| Biological source | Homo sapiens (human) |
| Cellular location | Secreted: P00797 |
| Total number of polymer chains | 2 |
| Total formula weight | 75767.42 |
| Authors | Bocskei, Z. (deposition date: 2010-09-03, release date: 2010-10-13, Last modification date: 2020-07-29) |
| Primary citation | Scheiper, B.,Matter, H.,Steinhagen, H.,Stilz, U.,Bocskei, Z.,Fleury, V.,McCort, G. Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors. Bioorg.Med.Chem.Lett., 20:6268-6272, 2010 Cited by PubMed: 20850300DOI: 10.1016/j.bmcl.2010.08.092 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.78 Å) |
Structure validation
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