3OAW

4-Methylpteridineones as Orally Active and Selective PI3K/mTOR Dual Inhibitors

Summary for 3OAW

• Entry DOI: 10.2210/pdb3oaw/pdb
• Related: 3ML8 3ML9
• Descriptor: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 2-amino-4-methyl-8-(1-methylethyl)-6-(1H-pyrazol-4-yl)pteridin-7(8H)-one (3 entities in total)
• Functional Keywords: phosphoinositide kinase, transferase-transferase, inhibition, inhibitor complex., transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 111012.41

Authors

Knighton, D.R.,Greasley, S.E.,Rodgers, C.M.-L. (deposition date: 2010-08-05, release date: 2010-09-22, Last modification date: 2024-02-21)

• Primary citation: Liu, K.K.,Bagrodia, S.,Bailey, S.,Cheng, H.,Chen, H.,Gao, L.,Greasley, S.,Hoffman, J.E.,Hu, Q.,Johnson, T.O.,Knighton, D.,Liu, Z.,Marx, M.A.,Nambu, M.D.,Ninkovic, S.,Pascual, B.,Rafidi, K.,Rodgers, C.M.,Smith, G.L.,Sun, S.,Wang, H.,Yang, A.,Yuan, J.,Zou, A.; 4-methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors.; Bioorg.Med.Chem.Lett., 20:6096-6099, 2010; PubMed: 20817449; DOI: 10.1016/j.bmcl.2010.08.045

Experimental method

X-RAY DIFFRACTION (2.75 Å)