3O73

Crystal structure of quinone reductase 2 in complex with the indolequinone MAC627

3O73 の概要

• エントリーDOI: 10.2210/pdb3o73/pdb
• 関連するPDBエントリー: 1QR2
• 分子名称: Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
• 機能のキーワード: quinone reductase 2, nqo2, oxidoreductase, flavoprotein, indolequinone mac627, fad, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P16083
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 56145.62

構造登録者

Dufour, M.,Yan, C.,Colucci, M.A.,Siegel, D.,Li, Y.,De Matteis, C.I.,Ross, D.,Moody, C.J. (登録日: 2010-07-30, 公開日: 2011-05-11, 最終更新日: 2023-09-06)

• 主引用文献: Dufour, M.,Yan, C.,Siegel, D.,Colucci, M.A.,Jenner, M.,Oldham, N.J.,Gomez, J.,Reigan, P.,Li, Y.,De Matteis, C.I.,Ross, D.,Moody, C.J.; Mechanism-Based Inhibition of Quinone Reductase 2 (NQO2): Selectivity for NQO2 over NQO1 and Structural Basis for Flavoprotein Inhibition.; Chembiochem, 12:1203-1208, 2011; PubMed: 21506232; DOI: 10.1002/cbic.201100085

実験手法

X-RAY DIFFRACTION (2 Å)