3O2D

Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody

3O2D の概要

• エントリーDOI: 10.2210/pdb3o2d/pdb
• 分子名称: ibalizumab light chain, ibalizumab heavy chain, T-cell surface glycoprotein CD4, ... (4 entities in total)
• 機能のキーワード: immunoglobulin fold, hiv-1 primary receptor, t cell coreceptor, monoclonal antibody, membrane, immune system
• 由来する生物種: Mus musculus (mouse); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P01730
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 69577.77

構造登録者

Freeman, M.M.,Seaman, M.S.,Rits-Volloch, S.,Hong, X.,Ho, D.D.,Chen, B. (登録日: 2010-07-22, 公開日: 2010-12-22, 最終更新日: 2011-07-13)

• 主引用文献: Freeman, M.M.,Seaman, M.S.,Rits-Volloch, S.,Hong, X.,Kao, C.Y.,Ho, D.D.,Chen, B.; Crystal Structure of HIV-1 Primary Receptor CD4 in Complex with a Potent Antiviral Antibody.; Structure, 18:1632-1641, 2010; PubMed: 21134642; DOI: 10.1016/j.str.2010.09.017

実験手法

X-RAY DIFFRACTION (2.19 Å)