3NWB

Rat COMT in complex with a fluorinated desoxyribose-containing bisubstrate inhibitor avoids hydroxyl group

3NWB の概要

• エントリーDOI: 10.2210/pdb3nwb/pdb
• 関連するPDBエントリー: 3NW9 3NWE 3OZR 3OZS 3OZT
• 分子名称: Catechol O-methyltransferase, MAGNESIUM ION, CHLORIDE ION, ... (7 entities in total)
• 機能のキーワード: methyltransferase, neurotransmitter degradation, alternative initiation, catecholamine metabolism, cell membrane, magnesium, membrane, metal-binding, phosphoprotein, s-adenosyl-l-methionine, signal-anchor, transmembrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Rattus norvegicus (rat)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25744.92

構造登録者

Ehler, A.,Schlatter, D.,Stihle, M.,Benz, J.,Rudolph, M.G. (登録日: 2010-07-09, 公開日: 2011-08-03, 最終更新日: 2024-03-20)

• 主引用文献: Ellermann, M.,Lerner, C.,Burgy, G.,Ehler, A.,Bissantz, C.,Jakob-Roetne, R.,Paulini, R.,Allemann, O.,Tissot, H.,Grunstein, D.,Stihle, M.,Diederich, F.,Rudolph, M.G.; Catechol-O-methyltransferase in complex with substituted 3'-deoxyribose bisubstrate inhibitors; Acta Crystallogr.,Sect.D, 68:253-260, 2012; PubMed: 22349227; DOI: 10.1107/S0907444912001138

実験手法

X-RAY DIFFRACTION (1.3 Å)