3NW9

Rat COMT in complex with a methylpurin-containing bisubstrate inhibitor

3NW9 の概要

• エントリーDOI: 10.2210/pdb3nw9/pdb
• 関連するPDBエントリー: 3NWB 3NWE 3OZR 3OZS 3OZT
• 分子名称: Catechol O-methyltransferase, MAGNESIUM ION, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: methyltransferase, neurotransmitter degradation, alternative initiation, catecholamine metabolism, cell membrane, magnesium, membrane, metal-binding, s-adenosyl-l-methionine, signal-anchor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Rattus norvegicus (rat)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25667.30

構造登録者

Ehler, A.,Schlatter, D.,Stihle, M.,Benz, J.,Rudolph, M.G. (登録日: 2010-07-09, 公開日: 2011-03-16, 最終更新日: 2024-03-20)

• 主引用文献: Ellermann, M.,Paulini, R.,Jakob-Roetne, R.,Lerner, C.,Borroni, E.,Roth, D.,Ehler, A.,Schweizer, W.B.,Schlatter, D.,Rudolph, M.G.,Diederich, F.; Molecular Recognition at the Active Site of Catechol-O-methyltransferase (COMT): Adenine Replacements in Bisubstrate Inhibitors; Chemistry, 17:6369-6381, 2011; PubMed: 21538606; DOI: 10.1002/chem.201003648

実験手法

X-RAY DIFFRACTION (1.65 Å)