3NTY
Crystal structure of AKR1C1 in complex with NADP and 5-Phenyl,3-chlorosalicylic acid
Summary for 3NTY
Entry DOI | 10.2210/pdb3nty/pdb |
Descriptor | Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-chloro-4-hydroxybiphenyl-3-carboxylic acid, ... (5 entities in total) |
Functional Keywords | aldo-keto reductase, 20 alpha hydroxysteroid dehydrogenase, akr1c1, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q04828 |
Total number of polymer chains | 1 |
Total formula weight | 37896.81 |
Authors | Dhagat, U.,El-Kabbani, O. (deposition date: 2010-07-06, release date: 2011-04-13, Last modification date: 2023-11-01) |
Primary citation | El-Kabbani, O.,Dhagat, U.,Soda, M.,Endo, S.,Matsunaga, T.,Hara, A. Probing the inhibitor selectivity pocket of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis Bioorg.Med.Chem.Lett., 21:2564-2567, 2011 Cited by PubMed: 21414777DOI: 10.1016/j.bmcl.2011.01.076 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
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