3NTY

Crystal structure of AKR1C1 in complex with NADP and 5-Phenyl,3-chlorosalicylic acid

3NTY の概要

• エントリーDOI: 10.2210/pdb3nty/pdb
• 分子名称: Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-chloro-4-hydroxybiphenyl-3-carboxylic acid, ... (5 entities in total)
• 機能のキーワード: aldo-keto reductase, 20 alpha hydroxysteroid dehydrogenase, akr1c1, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q04828
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37896.81

構造登録者

Dhagat, U.,El-Kabbani, O. (登録日: 2010-07-06, 公開日: 2011-04-13, 最終更新日: 2023-11-01)

• 主引用文献: El-Kabbani, O.,Dhagat, U.,Soda, M.,Endo, S.,Matsunaga, T.,Hara, A.; Probing the inhibitor selectivity pocket of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis; Bioorg.Med.Chem.Lett., 21:2564-2567, 2011; PubMed: 21414777; DOI: 10.1016/j.bmcl.2011.01.076

実験手法

X-RAY DIFFRACTION (1.87 Å)