3NTY
Crystal structure of AKR1C1 in complex with NADP and 5-Phenyl,3-chlorosalicylic acid
3NTY の概要
エントリーDOI | 10.2210/pdb3nty/pdb |
分子名称 | Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-chloro-4-hydroxybiphenyl-3-carboxylic acid, ... (5 entities in total) |
機能のキーワード | aldo-keto reductase, 20 alpha hydroxysteroid dehydrogenase, akr1c1, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm: Q04828 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 37896.81 |
構造登録者 | |
主引用文献 | El-Kabbani, O.,Dhagat, U.,Soda, M.,Endo, S.,Matsunaga, T.,Hara, A. Probing the inhibitor selectivity pocket of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis Bioorg.Med.Chem.Lett., 21:2564-2567, 2011 Cited by PubMed: 21414777DOI: 10.1016/j.bmcl.2011.01.076 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.87 Å) |
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