3NSS

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active sites

Summary for 3NSS

• Entry DOI: 10.2210/pdb3nss/pdb
• Related: 3BEQ
• Descriptor: Neuraminidase, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: 6-bladed beta-propeller, hydrolase, calcium binding, glycosylation
• Biological source: Influenza A virus
• Cellular location: Virion membrane: C3W5S3
• Total number of polymer chains: 2
• Total formula weight: 87304.13

Authors

Li, Q.,Qi, J.X.,Zhang, W.,Vavricka, C.J.,Shi, Y.,Gao, G.F. (deposition date: 2010-07-02, release date: 2010-09-22, Last modification date: 2024-10-30)

Primary citation

Li, Q.,Qi, J.X.,Zhang, W.,Vavricka, C.J.,Shi, Y.,Wei, J.H.,Feng, E.G.,Shen, J.S.,Chen, J.L.,Liu, D.,He, J.H.,Yan, J.H.,Liu, H.,Jiang, H.L.,Teng, M.K.,Li, X.B.,Gao, G.F.
The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site
Nat.Struct.Mol.Biol., 17:1266-1268, 2010

PubMed Abstract: Influenza A virus neuraminidase can be classified into groups 1 and 2 on the basis of its primary structure. The main structural feature of group 1 neuraminidase is an extra cavity in the active site, the 150-cavity. Here we present the crystal structure of neuraminidase from the 2009 pandemic H1N1 influenza strain. In contrast to other characterized N1 neuraminidases, which are all members of group 1, 2009 H1N1 neuraminidase does not have a 150-cavity.

PubMed: 20852645
DOI: 10.1038/nsmb.1909

Experimental method

X-RAY DIFFRACTION (1.902 Å)