3NSS

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active sites

3NSS の概要

• エントリーDOI: 10.2210/pdb3nss/pdb
• 関連するPDBエントリー: 3BEQ
• 分子名称: Neuraminidase, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: 6-bladed beta-propeller, hydrolase, calcium binding, glycosylation
• 由来する生物種: Influenza A virus
• 細胞内の位置: Virion membrane: C3W5S3
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 87304.13

構造登録者

Li, Q.,Qi, J.X.,Zhang, W.,Vavricka, C.J.,Shi, Y.,Gao, G.F. (登録日: 2010-07-02, 公開日: 2010-09-22, 最終更新日: 2024-10-30)

主引用文献

Li, Q.,Qi, J.X.,Zhang, W.,Vavricka, C.J.,Shi, Y.,Wei, J.H.,Feng, E.G.,Shen, J.S.,Chen, J.L.,Liu, D.,He, J.H.,Yan, J.H.,Liu, H.,Jiang, H.L.,Teng, M.K.,Li, X.B.,Gao, G.F.
The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site
Nat.Struct.Mol.Biol., 17:1266-1268, 2010

PubMed Abstract: Influenza A virus neuraminidase can be classified into groups 1 and 2 on the basis of its primary structure. The main structural feature of group 1 neuraminidase is an extra cavity in the active site, the 150-cavity. Here we present the crystal structure of neuraminidase from the 2009 pandemic H1N1 influenza strain. In contrast to other characterized N1 neuraminidases, which are all members of group 1, 2009 H1N1 neuraminidase does not have a 150-cavity.

PubMed: 20852645
DOI: 10.1038/nsmb.1909

実験手法

X-RAY DIFFRACTION (1.902 Å)