3NS7

Succinic Acid Amides as P2-P3 Replacements for Inhibitors of Interleukin-1beta Converting Enzyme (ICE or Caspase 1)

3NS7 の概要

• エントリーDOI: 10.2210/pdb3ns7/pdb
• 関連するBIRD辞書のPRD_ID: PRD_001011
• 分子名称: Caspase-1, (3S)-4-hydroxy-3-{[(2S)-4-{[2-(2-methyl-1H-benzimidazol-1-yl)ethyl]amino}-2-(1-methylethyl)-4-oxobutanoyl]amino}butanoic acid, ... (4 entities in total)
• 機能のキーワード: cysteine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm: P29466 P29466
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28975.34

構造登録者

Galatsis, P. (登録日: 2010-07-01, 公開日: 2011-08-17, 最終更新日: 2023-12-27)

• 主引用文献: Galatsis, P.,Caprathe, B.,Gilmore, J.,Thomas, A.,Linn, K.,Sheehan, S.,Harter, W.,Kostlan, C.,Lunney, E.,Stankovic, C.,Rubin, J.,Brady, K.,Allen, H.,Talanian, R.; Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1).; Bioorg.Med.Chem.Lett., 20:5184-5190, 2010; PubMed: 20656488; DOI: 10.1016/j.bmcl.2010.07.004

実験手法

X-RAY DIFFRACTION (2.6 Å)