3NP6

The crystal structure of Berberine bound to DNA d(CGTACG)

Summary for 3NP6

• Entry DOI: 10.2210/pdb3np6/pdb
• Related: 3NX5
• Descriptor: 5'-D(*CP*GP*TP*AP*CP*G)-3', CALCIUM ION, BERBERINE, ... (4 entities in total)
• Functional Keywords: drug-dna complex, double helix, b-dna, dna
• Total number of polymer chains: 4
• Total formula weight: 7613.31

Authors

Ferraroni, M.,Bazzicalupi, C.,Gratteri, P.,Bilia, A.R. (deposition date: 2010-06-28, release date: 2011-05-04, Last modification date: 2023-11-01)

Primary citation

Ferraroni, M.,Bazzicalupi, C.,Bilia, A.R.,Gratteri, P.
X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG)
Chem.Commun.(Camb.), 47:4917-4919, 2011

PubMed Abstract: The first crystal structures of Berberine and Sanguinarine intercalated with a d(CGTACG)(2) DNA sequence were obtained by X-ray diffraction analysis at 2.3 Å resolution. Both drugs join the end of two "two-molecules" DNA units, stacked in a non-classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)(2) DNA in its iminium form.

PubMed: 21431128
DOI: 10.1039/c1cc10971e

Experimental method

X-RAY DIFFRACTION (2.3 Å)