3NN6

Crystal structure of inhibitor-bound in active centre 6-hydroxy-L-nicotine oxidase from Arthrobacter nicotinovorans

3NN6 の概要

• エントリーDOI: 10.2210/pdb3nn6/pdb
• 関連するPDBエントリー: 3NGC 3NH3 3NHO 3NK0 3NK1 3NK2 3NN0
• 分子名称: 6-hydroxy-L-nicotine oxidase, 5-[(2R)-1-methylpyrrolidin-2-yl]pyridin-2-ol, (2R,3S,4S)-5-({[(acetylcarbamoyl)amino]methyl}[(3S,4R)-6-amino-3,4-dimethylhexyl]amino)-2,3,4-trihydroxypentyl [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name), ... (5 entities in total)
• 機能のキーワード: enantiomeric substrate- inhibitor, flavoenzymes, nicotine degradation, fad-binding fold, amino oxidase, fad binding, cytosol, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Arthrobacter nicotinovorans
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48867.90

構造登録者

Kachalova, G.S.,Bartunik, H.D. (登録日: 2010-06-23, 公開日: 2011-03-23, 最終更新日: 2023-09-06)

• 主引用文献: Kachalova, G.S.,Bourenkov, G.P.,Mengesdorf, T.,Schenk, S.,Maun, H.R.,Burghammer, M.,Riekel, C.,Decker, K.,Bartunik, H.D.; Crystal structure analysis of free and substrate-bound 6-hydroxy-L-nicotine oxidase from Arthrobacter nicotinovorans.; J.Mol.Biol., 396:785-799, 2010; PubMed: 20006620; DOI: 10.1016/j.jmb.2009.12.009

実験手法

X-RAY DIFFRACTION (2.19 Å)