3NDN

Crystal structure of O-succinylhomoserine sulfhydrylase from Mycobacterium tuberculosis covalently bound to pyridoxal-5-phosphate

3NDN の概要

• エントリーDOI: 10.2210/pdb3ndn/pdb
• 分子名称: O-succinylhomoserine sulfhydrylase (2 entities in total)
• 機能のキーワード: seattle structural genomics center for infectious disease, ssgcid, mycobacterium, tuberculosis, plp, schiff base, transamination, lyase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 178589.33

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2010-06-07, 公開日: 2010-06-16, 最終更新日: 2023-11-22)

• 主引用文献: Baugh, L.,Phan, I.,Begley, D.W.,Clifton, M.C.,Armour, B.,Dranow, D.M.,Taylor, B.M.,Muruthi, M.M.,Abendroth, J.,Fairman, J.W.,Fox, D.,Dieterich, S.H.,Staker, B.L.,Gardberg, A.S.,Choi, R.,Hewitt, S.N.,Napuli, A.J.,Myers, J.,Barrett, L.K.,Zhang, Y.,Ferrell, M.,Mundt, E.,Thompkins, K.,Tran, N.,Lyons-Abbott, S.,Abramov, A.,Sekar, A.,Serbzhinskiy, D.,Lorimer, D.,Buchko, G.W.,Stacy, R.,Stewart, L.J.,Edwards, T.E.,Van Voorhis, W.C.,Myler, P.J.; Increasing the structural coverage of tuberculosis drug targets.; Tuberculosis (Edinb), 95:142-148, 2015; PubMed: 25613812; DOI: 10.1016/j.tube.2014.12.003

実験手法

X-RAY DIFFRACTION (1.85 Å)