3NDB

Crystal structure of a signal sequence bound to the signal recognition particle

3NDB の概要

• エントリーDOI: 10.2210/pdb3ndb/pdb
• 関連するPDBエントリー: 2v3c
• 分子名称: Signal recognition particle 19 kDa protein, Signal recognition 54 kDa protein, SRP RNA, ... (4 entities in total)
• 機能のキーワード: protein-rna complex, signal recognition particle, signal sequence, ribonucleoprotein, signaling protein-rna complex, signaling protein/rna
• 由来する生物種: Methanocaldococcus jannaschii (Methanococcus jannaschii); 詳細
• 細胞内の位置: Cytoplasm (By similarity): Q58440 Q57565
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 104631.37

構造登録者

Hainzl, T.,Huang, S.,Sauer-Eriksson, E. (登録日: 2010-06-07, 公開日: 2011-02-23, 最終更新日: 2024-03-13)

主引用文献

Hainzl, T.,Huang, S.,Merilainen, G.,Brannstrom, K.,Sauer-Eriksson, A.E.
Structural basis of signal-sequence recognition by the signal recognition particle.
Nat.Struct.Mol.Biol., 18:389-391, 2011

PubMed Abstract: The signal recognition particle (SRP) recognizes and binds the signal sequence of nascent proteins as they emerge from the ribosome. We present here the 3.0-Å structure of a signal sequence bound to the Methanococcus jannaschii SRP core. Structural comparison with the free SRP core shows that signal-sequence binding induces formation of the GM-linker helix and a 180° flip of the NG domain-structural changes that ensure a hierarchical succession of events during protein targeting.

PubMed: 21336278
DOI: 10.1038/nsmb.1994

実験手法

X-RAY DIFFRACTION (3 Å)