3NCM

NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES

3NCM の概要

• エントリーDOI: 10.2210/pdb3ncm/pdb
• 分子名称: PROTEIN (NEURAL CELL ADHESION MOLECULE, LARGE ISOFORM) (1 entity in total)
• 機能のキーワード: cell adhesion, glycoprotein, heparin-binding, gpi-anchor, neural adhesion molecule, immunoglobulin fold, homophilic binding, cell adhesion protein
• 由来する生物種: Rattus norvegicus (Norway rat)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10581.34

構造登録者

Jensen, P.H.,Soroka, V.,Thomsen, N.K.,Berezin, V.,Bock, E.,Poulsen, F.M. (登録日: 1998-09-21, 公開日: 1999-07-23, 最終更新日: 2024-11-06)

主引用文献

Jensen, P.H.,Soroka, V.,Thomsen, N.K.,Ralets, I.,Berezin, V.,Bock, E.,Poulsen, F.M.
Structure and interactions of NCAM modules 1 and 2, basic elements in neural cell adhesion
Nat.Struct.Biol., 6:486-493, 1999

PubMed Abstract: The structure in solution of the second Ig-module fragment of residues 117-208 of NCAM has been determined. Like the first Ig-module of residues 20-116, it belongs to the I set of the immunogloblin superfamily. Module 1 and module 2 interact weakly, and the binding sites of this interaction have been identified. The two-module fragment NCAM(20-208) is a stable dimer. Removal of the charged residues in these sites in NCAM(20-208) abolishes the dimerization. Modeling the dimer of NCAM(20-208) to fit the interactions of these charges produces one coherent binding site for the formation of two antiparallel strands of the first two NCAM modules. This mode of binding could be a major element in trans-cellular interactions in neural cell adhesion.

PubMed: 10331878
DOI: 10.1038/8292

実験手法

SOLUTION NMR