3NCB

A mutant human Prolactin receptor antagonist H180A in complex with the extracellular domain of the human prolactin receptor

3NCB の概要

• エントリーDOI: 10.2210/pdb3ncb/pdb
• 関連するPDBエントリー: 3MZG 3N06 3N0P 3NCC 3NCE 3NCF
• 分子名称: Prolactin, Prolactin receptor, CARBONATE ION, ... (6 entities in total)
• 機能のキーワード: ph dependence, hematopoietic cytokine, hormone-hormone receptor complex, hormone/hormone receptor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P01236; Membrane ; Single-pass type I membrane protein . Isoform 7: Secreted: P16471
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46335.09

構造登録者

Kulkarni, M.V.,Tettamanzi, M.C.,Murphy, J.W.,Keeler, C.,Myszka, D.G.,Chayen, N.E.,Lolis, E.J.,Hodsdon, M.E. (登録日: 2010-06-04, 公開日: 2010-09-29, 最終更新日: 2023-09-06)

• 主引用文献: Kulkarni, M.V.,Tettamanzi, M.C.,Murphy, J.W.,Keeler, C.,Myszka, D.G.,Chayen, N.E.,Lolis, E.J.,Hodsdon, M.E.; Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation.; J.Biol.Chem., 285:38524-38533, 2010; PubMed: 20889499; DOI: 10.1074/jbc.M110.172072

実験手法

X-RAY DIFFRACTION (2.1 Å)