3NC4

The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors

3NC4 の概要

• エントリーDOI: 10.2210/pdb3nc4/pdb
• 分子名称: Glycogen phosphorylase, muscle form, N-({(2E)-2-[(2-hydroxyphenyl)methylidene]hydrazino}carbonothioyl)-beta-D-glucopyranosylamine (3 entities in total)
• 機能のキーワード: glycogenolysis, type 2 diabetes, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 98147.01

構造登録者

Alexacou, K.-M. (登録日: 2010-06-04, 公開日: 2011-01-05, 最終更新日: 2023-11-22)

• 主引用文献: Alexacou, K.M.,Tenchiu Deleanu, A.C.,Chrysina, E.D.,Charavgi, M.D.,Kostas, I.D.,Zographos, S.E.,Oikonomakos, N.G.,Leonidas, D.D.; The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors; Bioorg.Med.Chem., 18:7911-7922, 2010; PubMed: 20947361; DOI: 10.1016/j.bmc.2010.09.039

実験手法

X-RAY DIFFRACTION (2.07 Å)