3NB5

Human carbonic anhydrase II in complex with 2-(3-chloro-4-hydroxyphenyl)-N-(4-sulfamoylphenethyl)acetamide

3NB5 の概要

• エントリーDOI: 10.2210/pdb3nb5/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, 2-(3-chloro-4-hydroxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]acetamide, ... (5 entities in total)
• 機能のキーワード: drug design, natural product, sulfamate, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29999.59

構造登録者

Hofmann, A.,Osman, A.,Davis, R.A. (登録日: 2010-06-02, 公開日: 2011-04-20, 最終更新日: 2023-11-01)

• 主引用文献: Davis, R.A.,Hofmann, A.,Osman, A.,Hall, R.A.,Muhlschlegel, F.A.,Vullo, D.,Innocenti, A.,Supuran, C.T.,Poulsen, S.A.; Natural Product-Based Phenols as Novel Probes for Mycobacterial and Fungal Carbonic Anhydrases; J.Med.Chem., 54:1682-1692, 2011; PubMed: 21332115; DOI: 10.1021/jm1013242

実験手法

X-RAY DIFFRACTION (1.8 Å)