3N9J
Structure of human Glutathione Transferase Pi class in complex with Ethacraplatin
Summary for 3N9J
Entry DOI | 10.2210/pdb3n9j/pdb |
Descriptor | Glutathione S-transferase P, PLATINUM (II) ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (7 entities in total) |
Functional Keywords | transferase, glutathione, detoxification, ethacrynic acid, cisplatin, prodrug, ethacraplatin, platinum |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 48103.06 |
Authors | Parker, L.J.,Parker, M.W. (deposition date: 2010-05-30, release date: 2011-05-11, Last modification date: 2023-11-01) |
Primary citation | Parker, L.J.,Italiano, L.C.,Morton, C.J.,Hancock, N.C.,Ascher, D.B.,Aitken, J.B.,Harris, H.H.,Campomanes, P.,Rothlisberger, U.,De Luca, A.,Lo Bello, M.,Ang, W.H.,Dyson, P.J.,Parker, M.W. Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation. To be Published, |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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