3N9J

Structure of human Glutathione Transferase Pi class in complex with Ethacraplatin

3N9J の概要

• エントリーDOI: 10.2210/pdb3n9j/pdb
• 分子名称: Glutathione S-transferase P, PLATINUM (II) ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (7 entities in total)
• 機能のキーワード: transferase, glutathione, detoxification, ethacrynic acid, cisplatin, prodrug, ethacraplatin, platinum
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48103.06

構造登録者

Parker, L.J.,Parker, M.W. (登録日: 2010-05-30, 公開日: 2011-05-11, 最終更新日: 2023-11-01)

• 主引用文献: Parker, L.J.,Italiano, L.C.,Morton, C.J.,Hancock, N.C.,Ascher, D.B.,Aitken, J.B.,Harris, H.H.,Campomanes, P.,Rothlisberger, U.,De Luca, A.,Lo Bello, M.,Ang, W.H.,Dyson, P.J.,Parker, M.W.; Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation.; To be Published,

実験手法

X-RAY DIFFRACTION (1.85 Å)