3N8S

Crystal Structure of BlaC-E166A covalently bound with Cefamandole

3N8S の概要

• エントリーDOI: 10.2210/pdb3n8s/pdb
• 分子名称: Beta-lactamase, PHOSPHATE ION, (2R)-2-[(1R)-1-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-2-oxoethyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: penicillin binding protein, beta-lactam covalent adduct, hydrolase-antibiotic complex, hydrolase/antibiotic
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28869.15

構造登録者

Tremblay, L.W.,Blanchard, J.S. (登録日: 2010-05-28, 公開日: 2010-11-24, 最終更新日: 2017-11-08)

• 主引用文献: Tremblay, L.W.,Xu, H.,Blanchard, J.S.; Structures of the Michaelis Complex (1.2 A) and the Covalent Acyl Intermediate (2.0 A) of Cefamandole Bound in the Active Sites of the Mycobacterium tuberculosis beta-Lactamase K73A and E166A Mutants.; Biochemistry, 49:9685-9687, 2010; PubMed: 20961112; DOI: 10.1021/bi1015088

実験手法

X-RAY DIFFRACTION (2 Å)