3N8N

Crystal structure of 3-dehydroquinate dehydratase from Mycobacterium tuberculosis in complex with inhibitor 6

3N8N の概要

• エントリーDOI: 10.2210/pdb3n8n/pdb
• 関連するPDBエントリー: 3N76 3N7A 3N86 3N87
• 分子名称: 3-dehydroquinate dehydratase, (1R,4R,5R)-3-(tert-butylcarbamoyl)-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid (3 entities in total)
• 機能のキーワード: dehydroquinate dehydratase, arod, mycobacterium tuberculosis, shikimate pathway, drug discovery, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 24
• 化学式量合計: 383216.32

構造登録者

Dias, M.V.B.,Snee, W.C.,Bromfield, K.M.,Payne, R.,Palaninathan, S.K.,Ciulli, A.,Howard, N.I.,Abell, C.,Sacchettini, J.C.,Blundell, T.L. (登録日: 2010-05-28, 公開日: 2011-05-11, 最終更新日: 2023-09-06)

• 主引用文献: Dias, M.V.,Snee, W.C.,Bromfield, K.M.,Payne, R.J.,Palaninathan, S.K.,Ciulli, A.,Howard, N.I.,Abell, C.,Sacchettini, J.C.,Blundell, T.L.; Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis.; Biochem.J., 436:729-739, 2011; PubMed: 21410435; DOI: 10.1042/BJ20110002

実験手法

X-RAY DIFFRACTION (2.5 Å)