3N2R
Structure of neuronal nitric oxide synthase heme domain in complex with 6-(((3R,4R/3S,4S)-4-(3-Phenoxyphenoxy)pyrrolidin-3-yl)methyl)pyridin-2-amine
Summary for 3N2R
| Entry DOI | 10.2210/pdb3n2r/pdb |
| Descriptor | Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
| Functional Keywords | nitric oxide synthase inhibitor, oxidoreductase |
| Biological source | Rattus norvegicus (rat) |
| Cellular location | Cell membrane, sarcolemma ; Peripheral membrane protein : P29476 |
| Total number of polymer chains | 2 |
| Total formula weight | 100246.89 |
| Authors | Li, H.,Poulos, T.L. (deposition date: 2010-05-18, release date: 2010-08-18, Last modification date: 2023-09-06) |
| Primary citation | Xue, F.,Huang, J.,Ji, H.,Fang, J.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase. Bioorg.Med.Chem., 18:6526-6537, 2010 Cited by PubMed: 20673724DOI: 10.1016/j.bmc.2010.06.074 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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