3N2R

Structure of neuronal nitric oxide synthase heme domain in complex with 6-(((3R,4R/3S,4S)-4-(3-Phenoxyphenoxy)pyrrolidin-3-yl)methyl)pyridin-2-amine

3N2R の概要

• エントリーDOI: 10.2210/pdb3n2r/pdb
• 分子名称: Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: nitric oxide synthase inhibitor, oxidoreductase
• 由来する生物種: Rattus norvegicus (rat)
• 細胞内の位置: Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100246.89

構造登録者

Li, H.,Poulos, T.L. (登録日: 2010-05-18, 公開日: 2010-08-18, 最終更新日: 2023-09-06)

• 主引用文献: Xue, F.,Huang, J.,Ji, H.,Fang, J.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.; Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.; Bioorg.Med.Chem., 18:6526-6537, 2010; PubMed: 20673724; DOI: 10.1016/j.bmc.2010.06.074

実験手法

X-RAY DIFFRACTION (1.9 Å)