3MXF
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JQ1
3MXF の概要
エントリーDOI | 10.2210/pdb3mxf/pdb |
分子名称 | Bromodomain-containing protein 4, (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, IODIDE ION, ... (6 entities in total) |
機能のキーワード | bromodomain-containing protein 4 isoform long, brd4, bromodomain containing protein 4, cap, hunk1, mcap, mitotic chromosome associated protein, jq1, betsoff1, structural genomics consortium, sgc, cell cycle |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Nucleus (By similarity): O60885 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 15948.62 |
構造登録者 | Filippakopoulos, P.,Picaud, S.,Qi, J.,Keates, T.,Felletar, I.,Fedorov, O.,Muniz, J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Bradner, J.E.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2010-05-07, 公開日: 2010-10-06, 最終更新日: 2023-09-06) |
主引用文献 | Filippakopoulos, P.,Qi, J.,Picaud, S.,Shen, Y.,Smith, W.B.,Fedorov, O.,Morse, E.M.,Keates, T.,Hickman, T.T.,Felletar, I.,Philpott, M.,Munro, S.,McKeown, M.R.,Wang, Y.,Christie, A.L.,West, N.,Cameron, M.J.,Schwartz, B.,Heightman, T.D.,La Thangue, N.,French, C.A.,Wiest, O.,Kung, A.L.,Knapp, S.,Bradner, J.E. Selective inhibition of BET bromodomains. Nature, 468:1067-1073, 2010 Cited by PubMed: 20871596DOI: 10.1038/nature09504 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.6 Å) |
構造検証レポート
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