3MWU

Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95

3MWU の概要

• エントリーDOI: 10.2210/pdb3mwu/pdb
• 関連するPDBエントリー: 3I79 3I7B 3I7C 3IGO 3N51 3NCG
• 分子名称: Calmodulin-domain protein kinase 1, CALCIUM ION, 3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, ... (4 entities in total)
• 機能のキーワード: serine/threonine protein kinase, transferase, calcium-binding, atp-binding, calmodulin, bumped kinase inhibitor, bki, structural genomics, medical structural genomics of pathogenic protozoa, msgpp, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Cryptosporidium parvum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56685.57

構造登録者

Larson, E.T.,Merritt, E.A.,Medical Structural Genomics of Pathogenic Protozoa,Medical Structural Genomics of Pathogenic Protozoa (MSGPP) (登録日: 2010-05-06, 公開日: 2010-07-21, 最終更新日: 2023-09-06)

• 主引用文献: Murphy, R.C.,Ojo, K.K.,Larson, E.T.,Castellanos-Gonzalez, A.,Perera, B.G.,Keyloun, K.R.,Kim, J.E.,Bhandari, J.G.,Muller, N.R.,Verlinde, C.L.,White, A.C.,Merritt, E.A.,Van Voorhis, W.C.,Maly, D.J.; Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii.; ACS Med Chem Lett, 1:331-335, 2010; PubMed: 21116453; DOI: 10.1021/ml100096t

実験手法

X-RAY DIFFRACTION (1.98 Å)