3MOD

Crystal structure of the neutralizing HIV antibody 2F5 Fab fragment (recombinantly produced IgG) with 11 aa gp41 MPER-derived peptide

Summary for 3MOD

• Entry DOI: 10.2210/pdb3mod/pdb
• Related: 1TJH 3MNV 3MNW 3MNZ 3MO1 3MOA 3MOB
• Descriptor: gp41 MPER-derived peptide, ANTI-HIV-1 ANTIBODY 2F5 LIGHT CHAIN, ANTI-HIV-1 ANTIBODY 2F5 HEAVY CHAIN, ... (4 entities in total)
• Functional Keywords: hiv-1, hiv gp41 mper, 13h11, 2f5, z13, 4e10, fab antibody, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 49936.18

Authors

Nicely, N.I.,Dennison, S.M.,Kelsoe, G.,Liao, H.-X.,Alam, S.M.,Haynes, B.F. (deposition date: 2010-04-22, release date: 2010-11-17, Last modification date: 2023-09-06)

• Primary citation: Nicely, N.I.,Dennison, S.M.,Kelsoe, G.,Ueda, Y.,Liao, H.-X.,Alam, S.M.,Haynes, B.F.; Crystal Structure of a Non-Neutralizing HIV-1 gp41 Envelope Antibody Demonstrates Neutralization Mechanism of gp41 Antibodies; To be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)