3MO8

PWWP Domain of Human Bromodomain and PHD finger-containing protein 1 In Complex with Trimethylated H3K36 Peptide

3MO8 の概要

• エントリーDOI: 10.2210/pdb3mo8/pdb
• 関連するPDBエントリー: 3L42
• 分子名称: Peregrin, Histone H3.2 TRIMETHYLATED H3K36 PEPTIDE (3 entities in total)
• 機能のキーワード: peregrin, protein br140, histone h3 acetylation, transcription, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus : P55201 Q71DI3
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 16433.07

構造登録者

Lam, R.,Zeng, H.,Ni, S.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Min, J.,Wu, H.,Structural Genomics Consortium (SGC) (登録日: 2010-04-22, 公開日: 2010-06-02, 最終更新日: 2023-09-06)

主引用文献

Wu, H.,Zeng, H.,Lam, R.,Tempel, W.,Amaya, M.F.,Xu, C.,Dombrovski, L.,Qiu, W.,Wang, Y.,Min, J.
Structural and Histone Binding Ability Characterizations of Human PWWP Domains.
Plos One, 6:e18919-e18919, 2011

PubMed Abstract: The PWWP domain was first identified as a structural motif of 100-130 amino acids in the WHSC1 protein and predicted to be a protein-protein interaction domain. It belongs to the Tudor domain 'Royal Family', which consists of Tudor, chromodomain, MBT and PWWP domains. While Tudor, chromodomain and MBT domains have long been known to bind methylated histones, PWWP was shown to exhibit histone binding ability only until recently.

PubMed: 21720545
DOI: 10.1371/journal.pone.0018919

実験手法

X-RAY DIFFRACTION (1.69 Å)