3MNA

The crystal structure of human carbonic anhydrase Ii in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor

3MNA の概要

• エントリーDOI: 10.2210/pdb3mna/pdb
• 関連するPDBエントリー: 3MMF
• 分子名称: Carbonic anhydrase 2, ZINC ION, methyl N-{4-chloro-6-[(4-sulfamoylphenyl)amino]-1,3,5-triazin-2-yl}glycinate, ... (5 entities in total)
• 機能のキーワード: zinc metalloenzyme, inhibitor, sulfonamide, lyase, triazine, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29819.35

構造登録者

Avvaru, B.S.,Wagner, J.,Robbins, A.H.,Mckenna, R. (登録日: 2010-04-21, 公開日: 2011-04-20, 最終更新日: 2023-09-06)

• 主引用文献: Carta, F.,Garaj, V.,Maresca, A.,Wagner, J.,Avvaru, B.S.,Robbins, A.H.,Scozzafava, A.,McKenna, R.,Supuran, C.T.; Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.; Bioorg.Med.Chem., 19:3105-3119, 2011; PubMed: 21515057; DOI: 10.1016/j.bmc.2011.04.005

実験手法

X-RAY DIFFRACTION (1.5 Å)