3MME

Structure and functional dissection of PG16, an antibody with broad and potent neutralization of HIV-1

3MME の概要

• エントリーDOI: 10.2210/pdb3mme/pdb
• 関連するPDBエントリー: 3LRS
• 分子名称: PG16 HEAVY CHAIN FAB, PG16 LIGHT CHAIN FAB, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: neutralizing antibodies, long cdrh3, hiv-1, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 147086.44

構造登録者

Pancera, M.,McLellan, J.,Zhou, T.,Zhu, J.,Kwong, P. (登録日: 2010-04-19, 公開日: 2010-06-09, 最終更新日: 2023-09-06)

• 主引用文献: Pancera, M.,McLellan, J.S.,Wu, X.,Zhu, J.,Changela, A.,Schmidt, S.D.,Yang, Y.,Zhou, T.,Phogat, S.,Mascola, J.R.,Kwong, P.D.; Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1.; J.Virol., 84:8098-8110, 2010; PubMed: 20538861; DOI: 10.1128/JVI.00966-10

実験手法

X-RAY DIFFRACTION (3.97 Å)