3ML2
Human carbonic anhydsase II in complex with an aryl sulfonamide inhibitor
Summary for 3ML2
Entry DOI | 10.2210/pdb3ml2/pdb |
Related | 3MMF |
Descriptor | Carbonic anhydrase 2, ZINC ION, 2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(4-sulfamoylphenyl)acetamide, ... (5 entities in total) |
Functional Keywords | zinc metalloenzyme, metal-binding, lyase, sulfonamide, zinc ligands, inhibitor, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29834.96 |
Authors | Avvaru, B.S.,Wagner, J.,Robbins, A.H.,Mckenna, R. (deposition date: 2010-04-16, release date: 2011-04-20, Last modification date: 2023-09-06) |
Primary citation | Wagner, J.,Avvaru, B.S.,Robbins, A.H.,Scozzafava, A.,Supuran, C.T.,McKenna, R. Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations. Bioorg.Med.Chem., 18:4873-4878, 2010 Cited by PubMed: 20598552DOI: 10.1016/j.bmc.2010.06.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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