3ML2

Human carbonic anhydsase II in complex with an aryl sulfonamide inhibitor

3ML2 の概要

• エントリーDOI: 10.2210/pdb3ml2/pdb
• 関連するPDBエントリー: 3MMF
• 分子名称: Carbonic anhydrase 2, ZINC ION, 2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(4-sulfamoylphenyl)acetamide, ... (5 entities in total)
• 機能のキーワード: zinc metalloenzyme, metal-binding, lyase, sulfonamide, zinc ligands, inhibitor, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29834.96

構造登録者

Avvaru, B.S.,Wagner, J.,Robbins, A.H.,Mckenna, R. (登録日: 2010-04-16, 公開日: 2011-04-20, 最終更新日: 2023-09-06)

• 主引用文献: Wagner, J.,Avvaru, B.S.,Robbins, A.H.,Scozzafava, A.,Supuran, C.T.,McKenna, R.; Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations.; Bioorg.Med.Chem., 18:4873-4878, 2010; PubMed: 20598552; DOI: 10.1016/j.bmc.2010.06.028

実験手法

X-RAY DIFFRACTION (1.8 Å)