3MHC

Crystal structure of human cabonic anhydrase II in adduct with an adamantyl analogue of acetazolamide in a novel hydrophobic binding pocket

3MHC の概要

• エントリーDOI: 10.2210/pdb3mhc/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, (3S,5S,7S)-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)tricyclo[3.3.1.1~3,7~]decane-1-carboxamide, ... (4 entities in total)
• 機能のキーワード: carbonic anhydrase inhibitors, adamantyl, acetazolamide, lyase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29696.91

構造登録者

Avvaru, B.S. (登録日: 2010-04-07, 公開日: 2010-07-21, 最終更新日: 2023-09-06)

• 主引用文献: Avvaru, B.S.,Wagner, J.M.,Maresca, A.,Scozzafava, A.,Robbins, A.H.,Supuran, C.T.,McKenna, R.; Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.; Bioorg.Med.Chem.Lett., 20:4376-4381, 2010; PubMed: 20605094; DOI: 10.1016/j.bmcl.2010.06.082

実験手法

X-RAY DIFFRACTION (1.698 Å)